Deutsches Krebsforschungszentrum

The International Journal of Cancer accepts articles for publication only if the identity of the cell lines used in the experiments is certified by a genetic test. The specialist journal of the UICC (Union for International Cancer Control), which is edited chiefly by scientists from the German Cancer Research Center (DKFZ), thus takes a pioneering role in quality assurance of biomedical research results.

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Researchers have hypothesized that migrations into higher, colder latitudes may lead to evolution of fast-burning metabolisms that keep cells warm, boosting cold tolerance. Researchers of the German Cancer Research Center now show that a gene called THADA helps flies burn energy from fat. When the gene is knocked out in flies, they become obese and burn less energy. This finding may be a clue to previously observed correlations between ancestral latitudes and metabolism in humans.

Scientists from the German Cancer Research Center (DKFZ), the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) and the European Molecular Biology Laboratory (EMBL) used a new combination of analysis methods to study in single cells how blood stem cells in the bone marrow differentiate into mature blood cells. Their results have turned textbook knowledge of the past decades upside down.

Three scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have each been awarded one of the prestigious European Research Council (ERC) Advanced Grants comprising �2 million. One of the grants goes to Hans-Reimer Rodewald, who has developed a barcode system that makes it possible to track the path of immune system cells in the living organism. Tobias Dick is studying how reactive oxygen compounds in altered metabolism influence an organism's resistance. Bernd Bukau, who also pursues research at the University of Heidelberg, wants to find out how proteins are given their final outfit.

In order to adapt to changes in the environment, the brain produces new nerve cells (neurons) even at adult age. These young neurons are crucial for memory formation and learning. Scientists from the

German Cancer Research Center (DKFZ) and Heidelberg University Hospital have now discovered that a small peptide plays the role of a mediator in this process. In response to an external stimulus such as a varied environment, the mediator peptide boosts the proliferation of neural stem cells and neural progenitor cells.

A growing number of cases of oropharyngeal cancer are considered to be a consequence of infection with human papillomaviruses (HPV). Scientists at the German Cancer Research Center (DKFZ) have now revealed that a single blood sample test for specific antibodies can identify persons who are at a high risk of developing this type of cancer ten years or more before cancer diagnosis.

Radiation therapy of the lungs often leads to irreversible connective-tissue changes that cause functional impairments in the pulmonary tissue. Scientists from the German Cancer Research Center (DKFZ) have now been able to prevent, and even reverse this process in mice using an antibody.

Blood vessels: Much more than just tubes
The SFB Transregio 23, "Vascular Differentiation and Remodeling", will be hosting an international symposium to commemorate its 12th anniversary. The symposium will be held on March 27th and 28th at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) in Heidelberg. Vascular researchers from around the globe will lecture on how blood vessels influence their environment and thereby regulate important processes in the body.�Jumping gene� uncovers genetic networks involved in prostate and breast cancer
Mutations in tumor suppressor genes mean that they can no longer keep tumors from growing. In developing cancer, often several mutations come into play. Using "jumping genes," scientists from the Technical University of Munich (TUM) and the German Cancer Consortium (DKTK) together with teams from Great Britain and Spain have identified a number of genes that can influence the growth of prostate and breast tumors. They published their results in "Nature Genetics". Multi-talented Jack of all trades, miracle healer or the root of all evil?
On March 17, an unusual subject was on the agenda: Stem cells. More than 1000 high school students in ten German cities visited Institutes and Universities on a quest for stem cells in research and medicine. In Heidelberg, the German Cancer Research Center (DKFZ), the University Hospital and the University opened their doors for talks and lab visits for the second time. The idea is a European one: More than 27,000 young people set out on UniStem Day in Italy, Spain, Great Britain, Sweden, Poland, Serbia, Denmark and Germany, to find out more about this Jack of all trades in the world of cells.News Archive


Category: Cancer-2

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